Oligonucleotide pools are a highly diverse collection of single-stranded oligonucleotides synthesized using silicon-based DNA writing technology. Oligo pools are utilized in various applications such as the generation of CRISPR guide RNA (sgRNA) libraries, peptide screens, protein screens, and high-throughput reporter assays.This growth is primarily driven by Increasing Use of Synthesized Oligos in Molecular Diagnostics and Clinical Applications and Subsequent Improvements in Oligonucleotide Synthesis.
Major Players, such as Agilent Technology (United States), Eurogentec S.A (Kaneka Corporation) (Belgium), Merck Group (Sigmaaldrich) (Germany), Illumnia Inc. (United States), LGC Biosearch Technologies (United States), Eurofins Genomics (Germany), Roche Sequencing (United States), Integrated DNA Technologies (United States), Nitto Denko Avecia Inc (United States), General Biosystems (United States), Arbor Biosciences (United States), Twist Bioscience (United States), Genscript Biotech (United States), LC Sciences (United States) and Creative Biogene (United States) etc have either set up their manufacturing facilities or are planning to start new provision in the dominated region in the upcoming years.
In Febuary 2019, Thermo Fisher Scientific entered into an agreement with BioNTech (Germany). Through this agreement, BioNTech's messenger RNA (mRNA) manufacturing platform will be supported by Thermo Fisher through the supply of nucleotides, enzymes, and other critical raw materials.
- Increasing Use of Synthesized Oligos in Molecular Diagnostics and Clinical Applications
- Subsequent Improvements in Oligonucleotide Synthesis
- Price Erosion of Synthesized Oligos
- Lack of A Unified Set of Regulations for therapeutic Oligos
OpportunitiesIncreasing Government Investments and R&D Expenditure in Pharmaceutical and Biotechnology Companies and Rise in Venture Capital Investments in Developed Economies
ChallengesLarge-Scale Synthesis of Oligos and Delivery of Oligonucleotide Drugs to Specific Targets
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