About Integrin Alpha 4
Integrin alpha 4 (α4, alternatively referred to as CD49d) is a transmembrane protein that is a subunit of integrin receptors. It lacks an I-domain and does not go through disulfide-linked cleavage, in contrast to certain other alpha integrin subunits. It pairs with either the beta 1 (β1 or CD29) or beta 7 (β7) subunit to create two different integrin heterodimers: α4β1 (VLA-4) and α4β7 (LPAM-1). These integrins have important functions in cell migration and adhesion through interaction with many ligands. α4β1 interacts with fibronectin and vascular cell adhesion molecule 1 (VCAM-1), facilitating cell-extracellular matrix and cell-cell interactions. It is found on different immune cells, such as lymphocytes, monocytes, and eosinophils, and participates in their migration to areas of inflammation. α4β7 interacts with fibronectin and mucosal addressin cell adhesion molecule 1 (MAdCAM-1) and is mainly responsible for directing lymphocyte homing to the gut-associated lymphoid tissue. Because of their role in immune cell trafficking in inflammatory conditions, α4 integrins, especially α4β1, are important therapeutic targets, and natalizumab is an example of an α4-blocking antibody that has been used in the treatment of multiple sclerosis and Crohn's disease.
Attributes | Details |
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Study Period | 2020-2032 |
Base Year | 2024 |
Unit | Value (USD Million) |
Established and emerging Players should take a closer view at their existing organizations and reinvent traditional business and operating models to adapt to the future.
F. Hoffmann-La Roche AG (Basel, Switzerland), Pfizer Inc. (New York City, New York, USA), AbbVie Inc. (North Chicago, Illinois, USA), Eli Lilly and Company (Indianapolis, Indiana, USA), Merck & Co., Inc. (Rahway, New Jersey, USA), Bristol Myers Squibb (New York City, New York, USA), AstraZeneca PLC (Cambridge, United Kingdom), Sanofi S.A. (Paris, France), Gilead Sciences, Inc. (Foster City, California, USA) and Vertex Pharmaceuticals Incorporated (Boston, Massachusetts, USA) are some of the key players that are part of study coverage.
Segmentation Overview
AMA Research has segmented the market of Global Integrin Alpha 4 market by , Application (Multiple Sclerosis (MS), Inflammatory Bowel Disease (IBD), Melanoma, Celiac Disease and Other:) and Region.
On the basis of geography, the market of Integrin Alpha 4 has been segmented into South America (Brazil, Argentina, Rest of South America), Asia Pacific (China, Japan, India, South Korea, Taiwan, Australia, Rest of Asia-Pacific), Europe (Germany, France, Italy, United Kingdom, Netherlands, Rest of Europe), MEA (Middle East, Africa), North America (United States, Canada, Mexico). If we see Market by Type of Therapeutic Agent, the sub-segment i.e. TE-5232 will boost the Integrin Alpha 4 market. Additionally, the rising demand from SMEs and various industry verticals gives enough cushion to market growth.
About Approach
To evaluate and validate the market size various sources including primary and secondary analysis is utilized. AMA Research follows regulatory standards such as NAICS/SIC/ICB/TRCB, to have a better understanding of the market. The market study is conducted on basis of more than 200 companies dealing in the market regional as well as global areas with the purpose to understand the companies positioning regarding the market value, volume, and their market share for regional as well as global.
Further to bring relevance specific to any niche market we set and apply a number of criteria like Geographic Footprints, Regional Segments of Revenue, Operational Centres, etc. The next step is to finalize a team (In-House + Data Agencies) who then starts collecting C & D level executives and profiles, Industry experts, Opinion leaders, etc., and work towards appointment generation.
The primary research is performed by taking the interviews of executives of various companies dealing in the market as well as using the survey reports, research institute, and latest research reports. Meanwhile, the analyst team keeps preparing a set of questionnaires, and after getting the appointee list; the target audience is then tapped and segregated with various mediums and channels that are feasible for making connections that including email communication, telephonic, skype, LinkedIn Group & InMail, Community Forums, Community Forums, open Survey, SurveyMonkey, etc.