The CD40 ligand or CD40 pathway is widely recognized for its prominent role in immune regulation and homeostasis. CD40 is a surface antigen expressed on B cells and the CD40 ligand (CD40L) is expressed on activated T cells. Interaction between CD40 and CD40L is difficult for proliferation and isotype switching in the context of a response to a T-celldependent antigen. Patients with X-linked hyper-IgM syndrome (HIGMX-1) in their CD40L gene are unable to switch from IgM to IgG, IgE and IgA. Mice with a disrupted CD40 gene fail to undergo isotype switching to T-cell-dependent antigens but respond generally to T-independent antigens.This growth is primarily driven by Rising Prevalence of Cancer Worldwide and Government Initiative to Improve Healthcare Services.
Globally, a noticeable market trend is evident Rising Usage of CD40 in Cancer Treatment. Major Players, such as Biogen, Inc. (United States), Bristol-Myers Squibb Company (United States), eTheRNA Immunotherapies NV (Belgium), ImmuNext, Inc. (United States), Juno Therapeutics Inc. (United States), MedImmune, LLC (United States), Targovax AS (Norway), XL-protein GmbH (Germany) and FUJIFILM Irvine Scientific (United States) etc have either set up their manufacturing facilities or are planning to start new provision in the dominated region in the upcoming years.
Key Developments in the Market:
On July 26, 2017 - Jazz Pharmaceuticals plc today announced that it has entered into a license agreement with XL-protein GmbH for the rights to develop, manufacture and commercialize products using XLp's PASylation Technology to extend the plasma half-life of selected asparaginase product candidates.
- Rising Prevalence of Cancer Worldwide
- Government Initiative to Improve Healthcare Services
- Rising Usage of CD40 in Cancer Treatment
- Government Regulations for Protein Therapeutics
Rising Research Activities on CD40 Ligand
Lack of Awareness about the Therapeutic Drug Treatment
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